Study looks at drug delivery with liposomes
Several chemotherapy drugs can be administered only in certain doses, because they are highly toxic to healthy cells, are and in what doses, the concentration of drug that enters the tumor cells may be very low. Scientists have examined the use of liposomes, hollow spheres of fat molecules, chemotherapy drugs directly to tumors. These liposomes melt and release their contents when exposed to heat. In a new study, Ana M. Ponce and Mark W. Dewhirst, DVM, Ph.D., Duke University Medical Center and colleagues injected rats with liposomal doxorubicin in sarcomas.The researchers monitored the rats continuously using magnetic resonance imaging to see how the liposomes distributed in the body. They also follow if it was more effective to inject the liposomes before, during or before and
during heating of the tumor, which triggers the liposomes to dissolve and release doxorubicin inside.Based on their findings, the researchers conclude that the distribution of the drug is most effective when the liposomes were given while the tumor is heated. Contact: Becky Levine, Duke University Medical Center News Office ---------------------------- Article adapted by Medical News Today in the press originals. ---------------------------- Other highlights in the third January JNCI Note: The Journal of National Cancer Institute is published by Oxford University Press is not affiliated with the National Cancer Institute.Recognition of the Journal of the National Cancer Institute has called on all reports. Visit the Journal online at jncicancerspectrum.oxfordjournals /.
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