The new compound library to speed drug discovery
Contact: Kelli Whitlock or David Cameron newsroomwi.mit.edu 617-258-5183 Whitehead Institute for Biomedical Research Stockwell leads a research team has compiled a collection of 2,000 small molecules (or compounds), a type of biological activity showed. What distinguishes this library, as well as similar collections Stockwell Group is also an algorithm that can do everything, including comments on each connection of up to 12,000 different functions per molecule develops.Essentially, says Stockwell, the annotation strategy that all information associated with the connection, which in turn gives scientists greater and more direct understanding of the molecules they study captures. In the September issue of the journal Chemistry and Biology, Stockwell and three other
employees from his lab published research showing the power of this annotated compound library. In a series of genetically altered cells originally derived from samples of lung cancer, tested Stockwell and his team to ban the substance library of any ability or prevent the growth of cancer cells.85 of the 2,000 compounds have shown this ability, a surprisingly high number considering that none of these compounds never tested for these properties. Stockwell check, and then referred to the information recorded for each cross-connection and found common characteristics of most of these 85 compounds divided. With this test discovered 12 new mechanisms that may be of interest to cancer research, says Stockwell. For typical compound libraries that lack an annotation system,
discovering these mechanisms have lasted for years.Stockwells group situated in a little over a week.Think Big Imagine a library of Alexandria for biologically active compounds, and these collections lot of potential. Even if 2000 connections is a fraction of all biologically active molecules (which in turn is a subset of all compounds), Stockwell platform can be extended indefinitely. Said David Root, project scientist in
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