The treatment of solid tumors can be improved with the new target for cancer therapy
To attack and kill malignant cells that surround and support a cancer can stop tumor growth in mice, reports a research group at the University of Chicago Medical Center, in the first edition of March 2008 in the journal Cancer Research. The discovery provides a new approach to treating tumors that are resistant to standard therapy. Many solid tumors develop elaborate mechanisms to avoid recognition and elimination by the immune system. Due to their genetic instability, which often discard the tumor antigen-presenting cell surface structures that alert the immune system, these cells are harmful.Without these flags, the white blood cells not to recognize and destroy infected or cancerous cells. These tumors grow quickly and are often resistant to treatment with chemotherapy or
efforts to increase the immune response to tumor cells.But can accumulate the stroma, the layers of cells surrounding the tumor, tumor antigens and present them on their surface. These cells retain the surrounding genetically stable molecules, tumor antigens, which makes them a good target for immunotherapy, and they often play a catalytic role in tumor growth. We already knew that targeted the stroma is essential for the eradication of established large tumors, because the stroma is like the root of the tumor, said study author Hans Schreiber, MD, PhD, professor of pathology at the University of Chicago.However, the effects of current treatments that target stroma are usually transient and not specific for cancer.
Because cancer is a genetic disease, he said, we
wonder whether the mutant proteins are released into the environment and reflected in the stroma. If so, you can go to the root of cancer at a specific stop or remove a cancer tumor. T cells were injected, the warriors of the immune system in mice with large established tumors. These T cells specifically designed to recognize the tumor antigen, have no direct impact on cancer cells, but managed to kill stromal cells. This reduction Pages: [1] 2